TABLE 2

IC50 values for inhibition of uptake of 50 nM [3H]adenosine into PbENT1-expressing and PfENT1-expressing yeast by the PfENT1 inhibitors identified by Frame et al. (2015b)

IC50 values are means ± S.D. from three experiments. Compounds are numbered as in Frame et al. (2015b), with rank-order number from the HTS. Chembridge catalog numbers of the compounds are in the Materials and Methods. The compound names are in Frame et al., (2015b).

CompoundStructurePbENT1 IC50PfENT1 IC50Pb:Pf
nMnM
1Embedded Image3.4 ± 0.74.8 ± 0.50.7
2Embedded Image16 ± 7.233.5 ± 6.50.47
3Embedded Image5.4 ± 2.37 ± 0.40.77
4Embedded Image21.6 ± 2.323.1 ± 3.50.93
5Embedded Image56 ± 1454.5 ± 7.21.02
6Embedded Image27 ± 714 ± 2.71.93
7Embedded Image12.3 ± 3.215 ± 2.30.82
13Embedded Image11.6 ± 3.110.3 ± 2.41.12
19Embedded Image17 ± 3.642.5 ± 2.50.4