TABLE 3

IC50 values for inhibition of P. berghei parasite proliferation in 24-hour ex vivo culture

Compound numbers refer to PfENT1 inhibitors as per Table 2 and from Frame et al. (2015b). Data are means ± S.E.M. from two independent experiments.

CompoundIC50P. berghei Parasites Ex Vivo CultureIC50P. falciparum 3D7 Parasitesa
3, (μM)6.5 ± 0.6 19.2 ± 4.3
4, (μM)23.4 ± 1.015.0 ± 1.5
13, (μM)5.6 ± 0.4 6.9 ± 0.4
Amodiaquine, (μM) 3.9 ± 0.4
  • a From Frame et al. (2015b).