TABLE 1

Effects of GS967 on WT Na_V1.5, delKPQ, and F1760A onset and recovery from inactivation

	WT Na_V1.5		delKPQ		F1760A
	Control	1 µM GS967	Control	1 µM GS967	Control	1 µM GS967
Recovery from slow inactivation
Relative weight (%)	68.6 ± 2.5	5.5 ± 1.0^*	63.9 ± 2.9	13.6 ± 2.1^*^,^†	68.7 ± 1.4	28.8 ± 1.7^*^,^†
τ_fast (ms)	3.7 ± 0.3	9.2 ± 0.9^*	3.4 ± 0.2	39.0 ± 11.1^*^,^†	3.6 ± 0.3	9.3 ± 0.7^*
Relative weight (%)	31.4 ± 2.5	94.5 ± 1.0^*	36.1 ± 2.9	86.4 ± 2.1^*^,^†	31.3 ± 1.4	71.2 ± 1.7^*^,^†
τ_slow (ms)	238.5 ± 26.8	600.8 ± 24.3^*	224.0 ± 30.6	730.9 ± 62.2^*^,^†	107.1 ± 17.4^†	373.3 ± 23.9^*^,^†
n	18	18	11	11	14	14
Recovery from fast inactivation
Relative weight (%)		42.8 ± 2.8		57.0 ± 4.8		62.5 ± 2.3^†
τ_fast (ms)	3.2 ± 0.3	5.2 ± 0.7^*	3.5 ± 0.2	4.9 ± 1.1	3.4 ± 0.2	4.9 ± 0.4^*
Relative weight (%)		57.2 ± 2.8		43.0 ± 4.8^†		37.5 ± 2.3^†
τ_slow (ms)		602.1 ± 77.5		383.6 ± 86.0^†		338.7 ± 40.2^†
n	11	11	6	6	11	11
Onset of slow inactivation
τ (ms)	475.6 ± 29.7	28.8 ± 2.6^*	549.0 ± 49.5	30.1 ± 2.8^*	537.9 ± 70.4	31.1 ± 2.4^*
n	16	16	12	12	14	14