TABLE 1

Kinetics of MATE1-mediated transport of four structurally distinct substrates

SubstrateKtappJmaxJmax/Ktapp
µMpmol/cm−2·min−1Transport Efficiency × 10−3 cm/min
MPP34.5 ± 12.983.2 ± 29.32.4
NBD-MTMA105 ± 39.856.2 ± 20.30.5
Metformin336 ± 202344 ± 1811.0
Cimetidine2.2 ± 0.84.9 ± 1.72.2
  • Jmax, maximal rate of mediated substrate transport; Ktapp, apparent Michaelis constant of the transported substrate.