Concentration (μM) | Mean Normalized Cell Viability (%)a | n value | P value |
---|---|---|---|
bacopaside I | |||
0 | 108 ± 4.8 | 17 | N.S. |
0 (vehicle) | 100 ± 3.1 | 17 | — |
50 | 97 ± 2.1 | 8 | N.S. |
75 | 79 ± 4.2 | 8 | N.S. |
100 | 59 ± 3.2 | 8 | b |
bacopaside II | |||
0 | 113 ± 6.2 | 16 | N.S. |
0 (vehicle) | 100 ± 5.7 | 16 | — |
15 | 104 ± 18 | 8 | N.S. |
20 | 123 ± 17 | 8 | N.S. |
30 | 47 ± 5.7 | 8 | b |
HgCl2 | |||
100 | 16.1 ± 4.6 | 6 | b |
↵a Mean ± S.E.M. The percentage of viability was standardized as a percentage of the vehicle-treated mean value, measured as changes in AlumarBlue fluorescence signal intensity. See Materials and Methods for details.
↵b Statistically significant differences (P < 0.05), compared with vehicle-treated, were analyzed by analysis of variance with post hoc Dunnett’s multiple comparison test (GraphPad Prism). N.S. is not statistically significant.