Signaling | H1R | H2R | ||
---|---|---|---|---|
Pathway, Ligand, or Receptor | Reference | Pathway, Ligand, or Receptor | Reference | |
Main signaling pathway involved | Gq/11/PLC/Ca2+/PKC; Rac, RhoA | Gutowski et al. (1991), Notcovich et al. (2010) | Gs/AC/PKA | Panula et al. (2015) |
Other signaling pathways regulated | Gi/0; PLA2; AC/cAMP; NF-κB | Snider et al. (1984), Leurs et al. (1994), Seifert et al. (1994), Bakker et al. (2001), Prast and Philippu (2001) | Gq/11; PLA2; ERK1/2; PI3K | Leopoldt et al. (1997), Mettler et al. (2007), Bonini et al. (2011), Luo et al. (2013), Alonso et al. (2016) |
Classic reference ligand | Mepyramine | Sadek and Stark (2016) | Iodoaminopotentidine | Hirschfeld et al. (1992) |
Biased ligands | (−) trans-PAT; (±) cis-PAB | Moniri et al. (2004) | Famotidine; cimetidine; tiotidine; ranitidine | Alonso et al. (2014, 2015) |
Crosstalk with other receptors | ATP receptor; GR | Fitzsimons et al. (2004), Zappia et al. (2015) | β-adrenergic receptor; calcitonin receptor; PGE2 receptor | Monczor et al. (2003), Tubio et al. (2010) |
NF-κB, nuclear factor-κB; PGE2, prostaglandin E2; PI3K, phosphoinositide 3-kinase; PKA, protein kinase A; PKC, protein kinase C; PLA, phospholipase A.