TABLE 1

Pharmacological parameters of results shown in Fig. 3, A–C

Top and bottom are expressed as fold of basal, and log EC50 is expressed as logged EC50 (M).

ZnCl2
316 μM (N = 3)100 μM (N = 8)31.6 μM (N = 3)10 μM (N = 3)3.2 μM (N = 3)0 μM (N = 8)
GPR39-C3
 Top0.04 ± 0.0030.27 ± 0.5722.03 ± 0.7123.23 ± 0.8826.81 ± 1.9233.25 ± 2.31
 Bottom0.01 ± 0.001.09 ± 0.360.98 ± 0.210.99 ± 0.200.95 ± 0.191.00 ± 0.16
 Log EC50−8.63 ± 0.17−7.99 ± 0.04−7.09 ± 0.06−6.72 ± 0.06−6.40 ± 0.11−6.22 ± 0.11
 Hill slope0.82 ± 0.241.52 ± 0.170.79 ± 0.070.83 ± 0.080.72 ± 0.070.69 ± 0.05
LY2784544
 Top0.03 ± 0.0023.16 ± 0.5211.38 ± 0.457.99 ± 0.336.59 ± 0.517.10 ± 0.78
 Bottom0.01 ± 0.000.89 ± 0.251.02 ± 0.120.97 ± 0.060.92 ± 0.051.00 ± 0.03
 Log EC50−8.93 ± 0.27−8.17 ± 0.04−6.86 ± 0.06−6.26 ± 0.04−6.03 ± 0.07−5.81 ± 0.11
 Hill slope1.10 ± 0.661.45 ± 0.151.28 ± 0.171.61 ± 0.201.51 ± 0.251.27 ± 0.16
GSK2636771
 Top0.03 ± 0.0022.56 ± 0.5922.96 ± 3.4810.84 ± 0.99>153.7>73.15
 Bottom0.00 ± 0.000.83 ± 0.211.05 ± 0.160.99 ± 0.040.97 ± 0.051.00 ± 0.03
 Log EC50−7.96 ± 0.29−7.07 ± 0.04−5.42 ± 0.16−5.31 ± 0.07>-4.07>-4.25
 Hill slope0.64 ± 0.251.18 ± 0.111.04 ± 0.171.66 ± 0.211.50 ± 1.021.59 ± 0.86