ZnCl2 | ||||||
---|---|---|---|---|---|---|
316 μM (N = 3) | 100 μM (N = 8) | 31.6 μM (N = 3) | 10 μM (N = 3) | 3.2 μM (N = 3) | 0 μM (N = 8) | |
GPR39-C3 | ||||||
Top | 0.04 ± 0.00 | 30.27 ± 0.57 | 22.03 ± 0.71 | 23.23 ± 0.88 | 26.81 ± 1.92 | 33.25 ± 2.31 |
Bottom | 0.01 ± 0.00 | 1.09 ± 0.36 | 0.98 ± 0.21 | 0.99 ± 0.20 | 0.95 ± 0.19 | 1.00 ± 0.16 |
Log EC50 | −8.63 ± 0.17 | −7.99 ± 0.04 | −7.09 ± 0.06 | −6.72 ± 0.06 | −6.40 ± 0.11 | −6.22 ± 0.11 |
Hill slope | 0.82 ± 0.24 | 1.52 ± 0.17 | 0.79 ± 0.07 | 0.83 ± 0.08 | 0.72 ± 0.07 | 0.69 ± 0.05 |
LY2784544 | ||||||
Top | 0.03 ± 0.00 | 23.16 ± 0.52 | 11.38 ± 0.45 | 7.99 ± 0.33 | 6.59 ± 0.51 | 7.10 ± 0.78 |
Bottom | 0.01 ± 0.00 | 0.89 ± 0.25 | 1.02 ± 0.12 | 0.97 ± 0.06 | 0.92 ± 0.05 | 1.00 ± 0.03 |
Log EC50 | −8.93 ± 0.27 | −8.17 ± 0.04 | −6.86 ± 0.06 | −6.26 ± 0.04 | −6.03 ± 0.07 | −5.81 ± 0.11 |
Hill slope | 1.10 ± 0.66 | 1.45 ± 0.15 | 1.28 ± 0.17 | 1.61 ± 0.20 | 1.51 ± 0.25 | 1.27 ± 0.16 |
GSK2636771 | ||||||
Top | 0.03 ± 0.00 | 22.56 ± 0.59 | 22.96 ± 3.48 | 10.84 ± 0.99 | >153.7 | >73.15 |
Bottom | 0.00 ± 0.00 | 0.83 ± 0.21 | 1.05 ± 0.16 | 0.99 ± 0.04 | 0.97 ± 0.05 | 1.00 ± 0.03 |
Log EC50 | −7.96 ± 0.29 | −7.07 ± 0.04 | −5.42 ± 0.16 | −5.31 ± 0.07 | >-4.07 | >-4.25 |
Hill slope | 0.64 ± 0.25 | 1.18 ± 0.11 | 1.04 ± 0.17 | 1.66 ± 0.21 | 1.50 ± 1.02 | 1.59 ± 0.86 |