TABLE 7

Pharmacological parameters of results shown in Fig. 7

Top and bottom are expressed as fold of basal, and log EC50 is expressed as logged EC50 (M).

WTH17A/H19A
ZnCl2 (+) (N = 4)ZnCl2 (−) (N = 4)ZnCl2 (+) (N = 3)ZnCl2 (−) (N = 3)
GPR39-C3
 Top3.21 ± 0.083.07 ± 0.103.72 ± 0.143.75 ± 0.22
 Bottom1.18 ± 0.111.00 ± 0.101.07 ± 0.171.03 ± 0.11
 Log EC50−8.48 ± 0.10−8.00 ± 0.12−8.30 ± 0.14−7.17 ± 0.14
 Hill slope1.20 ± 0.300.94 ± 0.231.01 ± 0.290.90 ± 0.23
LY2784544
 Top3.94 ± 0.124.41 ± 0.383.77 ± 0.133.85 ± 0.16
 Bottom1.31 ± 0.221.00 ± 0.071.09 ± 0.271.03 ± 0.04
 Log EC50−8.51 ± 0.16−6.35 ± 0.14−8.72 ± 0.18−6.23 ± 0.07
 Hill slope0.63 ± 0.150.94 ± 0.180.88 ± 0.291.15 ± 0.15
GSK2636771
 Top3.68 ± 0.123.68 ± 0.633.74 ± 0.123.00 ± 0.11
 Bottom1.36 ± 0.121.01 ± 0.051.14 ± 0.151.01 ± 0.02
 Log EC50−7.97 ± 0.13−5.99 ± 0.25−8.16 ± 0.13−5.99 ± 0.05
 Hill slope0.86 ± 0.201.01 ± 0.280.95 ± 0.241.35 ± 0.16
  • WT, wild type.