TABLE 6

Pharmacological parameters of results shown in Fig. 6

Top and bottom are expressed as fold of basal, and log EC50 is expressed as logged EC50 (M).

WTH17A/H19A
ZnCl2 (+) (N = 8)ZnCl2 (−) (N = 8)ZnCl2 (+) (N = 5)ZnCl2 (−) (N = 5)
GPR39-C3
 Top30.27 ± 0.5733.25 ± 2.3125.87 ± 0.5529.07 ± 2.02
 Bottom1.09 ± 0.361.00 ± 0.161.08 ± 0.341.00 ± 0.24
 Log EC50−7.99 ± 0.04−6.22 ± 0.11−7.76 ± 0.04−6.43 ± 0.10
 Hill slope1.52 ± 0.170.69 ± 0.051.51 ± 0.180.84 ± 0.10
LY2784544
 Top23.16 ± 0.527.10 ± 0.7819.26 ± 0.567.23 ± 0.97
 Bottom0.89 ± 0.251.00 ± 0.030.91 ± 0.271.00 ± 0.06
 Log EC50−8.17 ± 0.04−5.81 ± 0.11−8.07 ± 0.04−5.91 ± 0.12
 Hill slope1.45 ± 0.151.27 ± 0.161.61 ± 0.231.57 ± 0.38
GSK2636771
 Top22.61 ± 0.59N.D.22.85 ± 0.93N.D.
 Bottom0.831 ± 0.211.00 ± 0.030.91 ± 0.271.00 ± 0.07
 Log EC50−7.068 ± 0.04>−4.00−6.94 ± 0.06>−4.00
 Hill slope1.179 ± 0.111.59 ± 0.861.05 ± 0.131.703 ± 0.75
  • N.D., could not determine; WT, wild type.