TABLE 4

Pharmacological parameters of the results shown in Fig. 4, A–C

Top and bottom are expressed as fold of basal, and log EC50 is expressed as logged EC50 (M).

ZnCl2
316 μM (N = 3)100 μM (N = 13)31.6 μM (N = 3)10 μM (N = 3)3.16 μM (N = 3)0 μM (N = 13)
GPR39-C3
 Top22.76 ± 0.897.68 ± 0.153.18 ± 0.13N.D.N.D.N.D.
 Bottom2.33 ± 0.241.38 ± 0.051.29 ± 0.04N.D.N.D.N.D.
 Log EC50−7.05 ± 0.07−6.72 ± 0.04−6.17 ± 0.08N.D.N.D.N.D.
 Hill slope0.87 ± 0.101.01 ± 0.081.70 ± 0.45N.D.N.D.N.D.
LY2784544
 Top18.86 ± 0.387.24 ± 0.191.96 ± 0.07N.D.N.D.N.D.
 Bottom2.04 ± 0.211.20 ± 0.101.12 ± 0.03N.D.N.D.N.D.
 Log EC50−7.75 ± 0.05−7.37 ± 0.08−6.47 ± 0.08N.D.N.D.N.D.
 Hill slope1.14 ± 0.121.13 ± 0.373.31 ± 3.73N.D.N.D.N.D.
GSK2636771
 Top16.41 ± 0.514.80 ± 0.12N.D.N.D.N.D.N.D.
 Bottom1.93 ± 0.181.10 ± 0.05N.D.N.D.N.D.N.D.
 Log EC50−7.12 ± 0.06−7.09 ± 0.05N.D.N.D.N.D.N.D.
 Hill slope1.10 ± 0.141.29 ± 0.17N.D.N.D.N.D.N.D.
  • N.D., could not determine.