TABLE 1

Potency of PF-06649298 and PF-06761281 (μM) at inhibiting C14-citrate uptake

IC50 (μM) in presence of
20 μM C14-citrate20 μM C14-citrate + 230 μM cold citrate
PF-0664929810.5 ± 3.00.58 ± 0.07
PF-067612813.4 ± 1.80.67 ± 0.09
  • Data are averages ± S.E.M. from three independent experiments combined.