TABLE 2

Citrate potency in the 20 μM C14-citrate uptake assay in the absence or presence of various concentrations of PF-06649298 and PF-06761281

VehiclePF-06649298 5 μMPF-06649298 2 μMPF-06761281 2 μMPF-06761281 1 μM
IC50 (μM)745 ± 111196 ± 3****422 ± 36**112 ± 11****226 ± 12***
Hill slope2.25 ± 0.121.02 ± 0.020.86 ± 0.040.97 ± 0.021.3 ± 0.06
  • Data are averages ± S.E.M. from three independent experiments with P values.

  • ** P < 0.01; *** P < 0.001; **** P < 0.0001, one-way ANOVA with Dunnett post hoc test.