TABLE 1

Concentration–response data for glycine site agonists at NMDA receptor subtypes

Concentration–response data for glycine site agonists at recombinant human and rat NMDA receptor subtypes measured using two-electrode voltage-clamp electrophysiology in the presence of 100–300 µM glutamate.

Receptor Subtype	Glycine Site Agonists	Receptor Species	EC₅₀ (µM)	pEC₅₀ ± S.E.M.	Rel. I_max (%)	n_H	N
GluN1/2A
	AICP	Human	0.066	7.18 ± 0.02	100 ± 2	1.3	15
	AICP	Rat	0.036	7.49 ± 0.05	92 ± 2	1.3	29
	Glycine	Human	1.2	5.91 ± 0.01	100 ± 1	1.7	6
	d-Serine	Human	1.8	5.75 ± 0.02	99 ± 1	1.8	5
	DCS	Human	22.0	4.65 ± 0.02	90 ± 2	1.3	6
	DCS	Rat	18.0	4.75 ± 0.01	91 ± 1	1.6	13
GluN1/2B
	AICP	Human	0.025	7.60 ± 0.19	10 ± 1	0.7	9
	AICP	Rat	0.014	7.86 ± 0.03	9 ± 0	1.1	14
	Glycine	Human	0.58	6.24 ± 0.02	101 ± 1	2.2	6
	d-Serine	Human	0.98	6.01 ± 0.05	97 ± 2	1.2	5
	DCS	Human	7.3	5.14 ± 0.06	63 ± 2	1.1	4
	DCS	Rat	8.3	5.08 ± 0.01	61 ± 0	1.4	12
GluN1/2C
	AICP	Human	0.0017	8.77 ± 0.04	353 ± 6	0.9	16
	AICP	Rat	0.0010	9.04 ± 0.03	339 ± 10	1.0	17
	Glycine	Human	0.33	6.48 ± 0.03	103 ± 1	1.7	5
	d-Serine	Human	0.47	6.33 ± 0.03	106 ± 1	1.6	5
	DCS	Human	4.4	5.36 ± 0.05	151 ± 5	1.3	4
	DCS	Rat	2.8	5.55 ± 0.01	197 ± 2	1.5	18
GluN1/2D
	AICP	Human	0.025	7.61 ± 0.03	27 ± 1	1.4	14
	AICP	Rat	0.031	7.51 ± 0.02	26 ± 1	1.5	11
	Glycine	Human	0.14	6.84 ± 0.04	100 ± 2	1.6	5
	d-Serine	Human	0.35	6.46 ± 0.03	101 ± 1	2.0	5
	DCS	Human	3.1	5.51 ± 0.06	76 ± 3	1.5	6
	DCS	Rat	3.2	5.50 ± 0.01	97 ± 0	1.6	6

N, number of oocytes; n_H, Hill coefficient; (Rel.) I_max, fitted maximal response relative to the maximal response to glycine.