Characterization of mIPSC waveforms and decay times in DG granule cells from hippocampal slices
Numbers are mean ± S.E.M. τ1 and τ2 are time constants when the decay of mIPSCs was fitted with two exponentials. Decay of mIPSCs in pattern d was fitted well with only one exponential. Abd (abundance): percentage of mIPSC numbers of a specific pattern (a, b, c, or d) versus total number of mIPSCs (patterns a + b + c + d). analyzed from a neuron.
| Pattern a Abd | Pattern b | Pattern c | Pattern d | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| τ1 (ms) | τ2 (ms) | Abd (%) | τ1 (ms) | τ2 (ms) | Abd (%) | τ1 (ms) | τ2 (ms) | Abd (%) | τ (ms) | Abd (%) | |
| CIV | 7.8 ± 0.4 | 32.0 ± 11.1 | 47.8 ± 2.6 | 14.1 ± 1.2 | 54.9 ± 11.3 | 36.6 ± 1.9 | 16.9 ± 0.6 | 15.6 ± 1.9 | |||
| CIE | 4.0 ± 0.3 | 12.9 ± 2.2 | 42.6 ± 0.9 | 14.6 ± 0.7 | 70.4 ± 9.2 | 21.8 ± 1.8* | 17.4 ± 0.7 | 35.6 ± 2.4* | |||
| WT | 7.6 ± 0.5 | 37.1 ± 10.5 | 46.2 ± 2.2 | 13.7 ± 0.6 | 35.9 ± 8.9 | 36.3 ± 1.9 | 17.0 ± 0.5 | 17.5 ± 0.7 | |||
| α4KO | 7.1 ± 0.4 | 28.0 ± 8.6 | 35.5 ± 1.9† | 13.8 ± 0.9 | 35.4 ± 8.6 | 35.3 ± 2.9 | 16.6 ± 1.1 | 29.2 ± 1.1† | |||
↵† P < 0.05, Abd of a pattern in α4KO group statistically different from that of WT group (one-way ANOVA followed by Sidak method for pairwise multiple comparisons).
↵* Abd of every pattern is not statistically significant between CIV and WT group. n = 6 neurons from three rats/group, n = 5 neurons from two mice/group.