TABLE 4

Examples of therapeutic peptides

Names	Sequences	Origin	Receptors	Mechanism	References
T4	NLLMAAS	Phage-displayed peptide library	Tie 2	Blocking the interaction between Ang1 and Tie2	Tournaire et al., 2004
C16Y	DFKLFAVYIKYR	Scrambled laminin-1 C16 sequence	Integrin α_Vβ₃ and α_Vβ₁	Antagonistically binding to integrin, blocking laminin-1 induced angiogenesis	Ponce et al., 2003
6a-p	KSVRGKGKGQKRKRKKSRYK	Exon 6a-encoded domain of VEGF	HSPG	Inhibiting the binding of VEGF and HSPG, blocking the angiogenesis pathway	Lee et al., 2010
Glypican-3 peptide	FVGEFFTDV	Glypican-3	CTL	Loading to tumor cells and enhancing the recognition of tumor cells by CTL	Nobuoka et al., 2013
^DPPA-1	NYSKPTDRQYHF	Phage-displayed peptide library	PD-1	Binding to immune checkpoint protein PD-1 and inhibiting the interaction between PD-1 and PD-L1	Chang et al., 2015
KLA	KLAKLAKKLAKLAK	Natural antibacterial peptide	Mitochondria membrane	Disrupting mitochondrial membrane and induce apoptosis (can be used in regulating stromal cell number in future)	An et al., 2010

HSPG, heparin sulfate proteoglycan.