Growth inhibition response (MTT assay, 72 hours) (GI50 values micromolars, concentration that inhibits growth by 50%) of ANI-7 and various breast cancer–targeting agents in a broad panel of cancer cell lines
Data represent the mean ± S.E.M. of four to five replicates.
| Cell Line | ANI-7 | Tamoxifen | Hydroxy Tamoxifen | Raloxifene | Anastrozole | Tyrphostin RG14620 | Amino Flavone |
|---|---|---|---|---|---|---|---|
| MCF-7a | 0.38 ± 0.03 | 7.7 ± 0.6 | 4.2 ± 1.2 | 8.7 ± 3.3 | 35 ± 16 | 12 ± 1 | 0.006 ± 0.001 |
| A431b | 0.51 ± 0.05 | 6.5 ± 1.0 | 8.8 ± 0.4 | 14 ± 2 | >50 | 12 ± 0.75 | 7.4 ± 0.7 |
| H460c | 3.0 ± 0.4 | 9.5 ± 0.3 | 2.5 ± 0.4 | 12 ± 0.8 | >50 | 16 ± 0.4 | 0.16 ± 0.05 |
| HT29d | 6.0 ± 0.2 | 8.2 ± 1.9 | 2.0 ± 0.1 | 11 ± 2 | >50 | 5.8 ± 1.5 | 21 ± 5 |
| A2780e | 13 ± 2 | 13 ± 1.2 | 7.1 ± 0.7 | 9.5 ± 0.4 | >50 | 10 ± 1.0 | 0.32 ± 0.09 |
| BE2-Cf | 18 ± 2 | 16 ± 0.3 | 2.8 ± 0.3 | 15 ± 0 | >50 | 10 ± 0.67 | 21 ± 2 |
| SMAg | 20 ± 2 | 12 ± 0.3 | 7.9 ± 0.2 | 16 ± 2 | >50 | 15 ± 2.0 | 14 ± 1 |
| SJ-G2h | 23 ± 2 | 12 ± 2 | 8.6 ± 0.5 | 17 ± 0 | >50 | 9.5 ± 1.3 | 12 ± 1 |
| Du145i | 27 ± 1 | 10 ± 3 | 8.9 ± 0.6 | 12 ± 0 | >50 | 11 ± 0.43 | 12 ± 1 |
| U87h | 36 ± 3 | 18 ± 2 | 9.5 ± 0.6 | 21 ± 1 | >50 | 13 ± 0.82 | 14 ± 1 |
| SW480d | 39 ± 3 | 16 ± 0.3 | 2.0 ± 0.1 | nd | >50 | 18 ± 0.86 | nd |
| MIAj | 42 ± 3 | 10 ± 0.3 | 6.0 ± 0.5 | 14 ± 2 | >50 | 12 ± 0.0 | 13 ± 2 |