Kinase inhibition data showing percentage kinase activity in the presence of 10 µM ANI-7
Data represent the mean ± S.E.M. of duplicate experiments.
| Kinase Classification | |||||
|---|---|---|---|---|---|
| Receptors | Phosphatidylinositol 3-kinase (PI3K)/mTOR pathway | ||||
| EGFR | 101 ± 1 | a | PDK1/PDPK1 | 95 ± 1.4 | a |
| ERBB2/HER2 | 95 ± 3 | a | SGK1 | 95 ± 0.8 | a |
| ERBB4/HER4 | 102 ± 6 | a | SGK2 | 93 ± 1.1 | a |
| IGF1R | 90 ± 7.2 | b | SGK3/SGKL | 99 ± 3.1 | a |
| PDGFRa | 87 ± 8.5 | a | AKT1 | 94 ± 2.3 | a |
| PDGFRb | 102 ± 2.3 | a | AKT2 | 91 ± 1.9 | a |
| Lipid kinases | AKT3 | 104 ± 2.0 | a | ||
| Choline kinase α | 97 ± 2.4 | b | COT1/MAP3K8 | 95 ± 0.8 | a |
| Choline kinase β | 97 ± 4.1 | b | GSK3a | 80 ± 0.3 | a |
| DGKβ | 93 ± 30 | b | GSK3b | 89 ± 1.5 | a |
| DGKγ | 83 ± 20 | b | mTOR/FRAP1 | 98 ± 0.7 | a |
| DGKζ | 88 ± 14 | b | ROCK1 | 95 ± 2.3 | a |
| PI3Kα | 84 ± 1.9 | a | ROCK2 | 98 ± 0.3 | a |
| PI3Kβ | 95 ± 6.9 | a | P70S6K | 103 ± 3.0 | b |
| PI3Kδ | 77 ± 8.3 | a | Mitogen-activated protein kinase pathway | ||
| PI3Kγ | 66 ± 12 | a | RAF1 | 106 ± 1.3 | a |
| PI4K2A | 94 ± 8.4 | b | ARAF | 100 ± 2.3 | a |
| PIP5K2A | 83 ± 0.6 | b | BRAF | 101 ± 1.2 | a |
| Sphingosine kinase 1 | 65 ± 23 | b | MEK1 | 101 ± 1.5 | a |
| Sphingosine kinase 2 | 80 ± 8.9 | b | MEK2 | 92 ± 0.3 | a |
| Others | ERK1 | 100 ± 1.6 | a | ||
| BRK | 91 ± 4.6 | a | ERK2/MAPK1 | 98 ± 0.7 | a |
| PKBa | 101 ± 0.2 | b | c-Src | 87 ± 4.6 | a |
| PKD1 | 119 ± 0.1 | b | |||
| PKBb | 99 ± 9.0 | b | |||