GPCR-related proteins/genes that are targets for approved drugs
| Examples of Proteins/Genes That Are Drug Targets | Examples of Drugs That Target These Proteins/Genes |
|---|---|
| Protein/gene category: enzymes involved in agonist synthesis | |
| Prostaglandin I2 synthase | Epoprostenol |
| Angiotensin I converting enzymes | Lisinopril |
| Dopamine beta-hydroxylase | Hydralazine |
| Coagulation factors (e.g., factor 10) | Rivaroxaban |
| Protein/gene category: enzymes involved in agonist degradation | |
| Monoamine oxidases A and B | Phenelzine |
| Catechol O-methyltransferase | Entacapone |
| Acetylcholinesterase | Neostigmine |
| Adenosine deaminase | Pentostatin |
| Dipeptidyl peptidase-4 | Sitagliptin |
| Protein/gene category: transporters of GPCR agonists | |
| Serotonin transporters | Citalopram |
| Dopamine transporters (SLC6A3) | Modafinil |
| ATP transporters (SLC25A4) | Clodronic acid |
| Protein/gene category: GPCR ligands | |
| C-C motif chemokine ligand 2 | Mimosine |
| Coagulation factor II, thrombin | Argatroban |
| Protein/gene category: regulators of second messenger signaling | |
| PDEs | |
| PDE1A-C | Vinpocetine |
| PDE4A-D | Roflumilast |
| Rho Kinases (ROCK1-2) | Fasudil |