Summary of potency and maximal response of class C GPCR allosteric modulator-mediated agonism for IP1 accumulation in HEK293A-mGlu5-low cells
Data represent the mean ± S.E.M. from four independent experiments performed in duplicate.
| Ligand | pEC50 | Emaxa |
|---|---|---|
| AZ12216052 | 5.56 ± 0.35 | 1.20 ± 0.06 |
| Cinacalcet | 5.08 ± 0.35 | 1.43 ± 0.06 |
| NPS2143 | 4.97 ± 0.12 | 1.44 ± 0.06 |
| CGP7930 | 4.46 ± 0.25 | 1.29 ± 0.17 |
↵a Maximal response to indicated agonist expressed as fold increase over basal IP1 levels.