PK parameters of 7OH MTX
PK parameters are presented as the mean ± S.D. (n = 5). The raw data were log-transformed and the significant difference analysis was done on the transformed data.
| PK Parameter | Control | LEF |
|---|---|---|
| 7OH MTX | ||
| t1/2 (h) | 0.91 ± 0.29 | 0.99 ± 0.19 |
| AUC (μg/ml*h) | 13.1 ± 4.6 | 44.2 ± 25.6* |
| CL (l/h per kilogram) | 0.83 ± 0.27 | 0.28 ± 0.13 |
| MRT0–t (h) | 0.82 ± 0.16 | 1.28 ± 0.18 |
See the illustration in Fig. 5 for details. CL, clearance; MRT0–t, mean residence time from time zero extrapolated until the end of the dosing interval; NA, not applicable; t1/2, elimination half-life.
↵* P < 0.01 (differences between four groups were analyzed using one-way analysis of variance).