TABLE 2

Average peak calcium transient measures following the coapplication of 3 mM choline and 1 μM PNU120596 in cells transfected with variants of the α7 receptor

Cells were pretreated with Ry (30 μM) or Xest. C (1 μM).

ReceptorVehicle (ΔF/Fθ)Ry (ΔF/Fθ)Xest. C (ΔF/Fθ)
α7endogenous4858.25% ± 468.65%1398.76% ± 382.33%1583.34% ± 240.76%
α7D44A2654.13% ± 498.24%1115.99% ± 234.19%1696.25% ± 259.46%
α7345–348A3322.11% ± 474.83%1965.54% ± 282.33%2647.60% ± 432.65%