TABLE 5

OAT1-mediated tenofovir transport efficiencies and SUA levels in species with or without functional uricase

*The mean value of SUA was calculated based on reported levels. The range of SUA is included in parenthesis. —, not applicable.

SpeciesWithout Uricase ActivityWith Uricase Activity
SUA*Tenofovir Transport EfficiencySUATenofovir Transport Efficiency
μMμl/mg/minμMμl/mg/min
Human318 (210–420) (Tan et al., 2016)63
Chimpanzee244 (120–360) (Fanelli and Beyer, 1974)61
Gorilla146 (130–160) (Fanelli and Beyer, 1974)49
Orangutan140 (110–170) (Fanelli and Beyer, 1974)69
Gibbon178 (120–300) (Fanelli and Beyer, 1974)52
Cynomolgus monkey36 (30–42) (Fanelli and Beyer, 1974)10
Squirrel monkey30 (12–60) (Fanelli and Beyer, 1974)15
Mouse53 (30–78) (Wu et al., 1994; So and Thorens, 2010)17
Rat67 (64–70) (Mazzali et al., 2001; Lu et al., 2016)15
Dog18 (Miller et al., 1951)25
Mean205 ± 7558.9 ± 8.341 ± 1916.5 ± 5.3