TABLE 1

Potencies of ANPs in inhibiting 6CF uptake by OAT1 species orthologs from human, cynomolgus monkey, mouse, rat, and dog

Statistical analyses were performed by one-way analysis of variance followed by Dunnett’s multiple comparisons test. N ≥ 2.

InhibitorIC50
HumanCynomolgus MonkeyMouseRatDog
μMμMμMμMμM
Adefovir71 ± 15220 ± 67*399 ± 147***263 ± 66*181 ± 4
Cidofovir88 ± 25181 ± 67237 ± 69**245 ± 19**185 ± 27
Tenofovir61 ± 14343 ± 40****165 ± 27*153 ± 17223 ± 64**

  • ↵* P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.