Potencies of ANPs in inhibiting 6CF uptake by OAT1 species orthologs from human, cynomolgus monkey, mouse, rat, and dog
Statistical analyses were performed by one-way analysis of variance followed by Dunnett’s multiple comparisons test. N ≥ 2.
Inhibitor | IC50 | ||||
---|---|---|---|---|---|
Human | Cynomolgus Monkey | Mouse | Rat | Dog | |
μM | μM | μM | μM | μM | |
Adefovir | 71 ± 15 | 220 ± 67* | 399 ± 147*** | 263 ± 66* | 181 ± 4 |
Cidofovir | 88 ± 25 | 181 ± 67 | 237 ± 69** | 245 ± 19** | 185 ± 27 |
Tenofovir | 61 ± 14 | 343 ± 40**** | 165 ± 27* | 153 ± 17 | 223 ± 64** |
↵* P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.