TABLE 4

Kinetic parameters of tenofovir uptake rate by OAT1 wild-type transporters and mutants at position 203

SpeciesAmino Acid at position 203 or Equivalent PositionKm
μM
HumanS72.6 ± 20
ChimpanzeeS44.2 ± 1.5
GorillaS56.0 ± 7.5
OrangutanS79.0 ± 16
GibbonS65.0 ± 2.4
GalagoS84.9 ± 24
cyOAT1 A203SS105 ± 27
Cynomolgus monkeyA254 ± 0.1
Squirrel monkeyA181 ± 60
MouseA138 ± 18
RatA139 ± 7.6
DogA157 ± 8.8
hOAT1 S203AA216 ± 19
  • S, Serine; A, Alanine.