TABLE 6

Kinetic parameters of [14C]-uric acid uptake by hOAT1 and cyOAT1 in HEK293 cells stably expressing the transporters

Student’s t test was performed to determine significant differences between the two groups. N ≥ 2.

ParameterHumanCynomolgus Monkey
Km (μM)571 ± 97.71070 ± 90**
Vmax (pmol/mg/min)1510 ± 2431040 ± 106
Vmax/Km (μl/mg/min)2.60.97
  • ** P < 0.01.