Kinetic parameters of [14C]-uric acid uptake by hOAT1 and cyOAT1 in HEK293 cells stably expressing the transporters
Student’s t test was performed to determine significant differences between the two groups. N ≥ 2.
| Parameter | Human | Cynomolgus Monkey |
|---|---|---|
| Km (μM) | 571 ± 97.7 | 1070 ± 90** |
| Vmax (pmol/mg/min) | 1510 ± 243 | 1040 ± 106 |
| Vmax/Km (μl/mg/min) | 2.6 | 0.97 |
↵** P < 0.01.