Temperature dependence of drug-block onset
The time course of block onset (τon) was measured at 22°C and 36°C by fitting an exponential function to drug-block data.
| τon | ||||||
|---|---|---|---|---|---|---|
| 22°C | 36°C | |||||
| Concentration 1 | Concentration 2 | Concentration 1 | Concentration 2 | Concentration 1 | Concentration 2 | |
| s | s | s | s | |||
| Verapamil | 100 | 300 | 5.30 | 2.97 | 1.24 | 0.86 |
| Cisapride | 30 | 100 | 10.96 | 5.95 | 2.59 | 1.08 |
| Bepridil | 100 | 1000 | 3.20 | 0.67 | 1.58 | 0.25 |
| Terfenadine | 100 | 1000 | 10.82 | 1.13 | 2.07 | 0.21 |
| Dofetilide | 100 | — | 30.30 | — | 7.43 | — |
| Diltiazem | 30 | — | 0.84 | — | — | — |