TABLE 2

Published Kir4.1 inhibitors

Compound	Drug Class	Kir4.1 IC₅₀	Reference
		µM
Fluoxetine	SSRI	15	Ohno et al. (2007)
Amitriptyline	TCA	89	This study
Chloroquine	Antimalarial	7	Marmolejo-Murillo et al. (2017b)
Nortriptyline	TCA	16–38^{^a}	Su et al. (2007)
Pentamidine	Antimicrobial	0.097^{^b}	Takanari et al. (2013), Aréchiga-Figueroa et al. (2017)
Quinacrine	Antimalarial	∼3	Marmolejo-Murillo et al. (2017a)
VU717	None	6	Raphemot et al. (2013)
VU0134992	None	0.97	This study

SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.
↵^a Voltage-dependent block; calculated at +30 and −110 mV, respectively.
↵^b Voltage-dependent block; calculated at +80 mV in inside-out patch-clamp experiments.