TABLE 1

Pharmacology and voltage-dependence of Ca_v1.2, Ca_v1.3, and mutant channels

Channel  (+ β₃ & α₂δ₁)	Nifedipine Log IC₅₀	Nifedipine Hill Slope	Nifedipine Max	FPL64176 Log EC₅₀	V_1/2inact.	V_1/2act.	ΔV_1/2act. FPL
			%		mV	mV	mV
Ca_v1.2	−7.59 ± 0.03	1.0 ± 0.1	90 ± 3	−6.95 ± 0.16	−41 ± 0.6	−20 ± 0.5	−26 ± 0.7
Ca_v1.2	N = 3–12	1.0 ± 0.1	90 ± 3	N = 3–8	N = 6	N = 6	N = 7
Ca_v1.3 (long)	−6.54 ± 0.04	0.78 ± 0.05	88 ± 2	−6.05 ± 0.08^{^a}	−36 ± 1.3	−30 ± 1.5	−10.2 ± 1.8
Ca_v1.3 (long)	N = 7	0.78 ± 0.05	88 ± 2	N = 3–7	N = 5	N = 9	N = 9
Ca_v1.3 42a (short)	−6.36 ± 0.02	1.0 ± 0.05	91 ± 2	ND	−40 ± 1.2	−28 ± 0.7	ND
Ca_v1.3 42a (short)	N = 5 to 6	1.0 ± 0.05	91 ± 2	ND	N = 5	N = 5	ND
Ca_v1.3/DHPi	∼ −4.0	ND	ND	ND	−27 ± 1.2	−22 ± 1.1	−9.5 ± 1.4
Ca_v1.3/DHPi	N = 2–16	ND	ND	ND	N = 5	N = 9	N = 6
Ca_v1.3/MV	−7.05 ± 0.04	1.3 ± 0.15	81 ± 2	−6.97 ± 0.05	−35 ± 0.5	−26 ± 1.1	ND
Ca_v1.3/MV	N = 5–7	1.3 ± 0.15	81 ± 2	N = 3–7	N = 6	N = 23	ND
Ca_v1.2/VM	−7.41 ± 0.07	0.83 ± 0.11	94 ± 4	ND	−38 ± 0.5	−24 ± 1.0	ND
Ca_v1.2/VM	N = 4–6	0.83 ± 0.11	94 ± 4	ND	N = 6	N = 8	ND
Ca_v1.3+	−7.00 ± 0.02	0.79 ± 0.02	87 ± 1	ND	−38 ± 1.6	−29 ± 0.8	ND
Ca_v1.3+	N = 6–8	0.79 ± 0.02	87 ± 1	ND	N = 7	N = 12	ND
Ca_v1.3+V	−7.37 ± 0.05	1.4 ± 0.16	83 ± 2	−6.97 ± 0.05	−42 ± 0.3	−28 ± 1.2	−8.2 ± 1.8
Ca_v1.3+V	N = 4–10	1.4 ± 0.16	83 ± 2	N = 3–7	N = 4	N = 8	N = 7
Ca_v1.3/PEEP	−6.73 ± 0.07	0.43 ± 0.02	80 ± 2	−5.93 ± 0.03	−36 ± 0.2	−27 ± 0.8	ND
Ca_v1.3/PEEP	N = 3–7	0.43 ± 0.02	80 ± 2	N = 4 to 5	N = 3	N = 6	ND
Ca_v1.3/N6	−6.93 ± 0.20^{^a}	0.52 ± 0.12	66 ± 5	−6.05 ± 0.15^a	−34 ± 0.6	−17 ± 0.8	ND
Ca_v1.3/N6	N = 5–9	0.52 ± 0.12	66 ± 5	N = 8–12	N = 5	N = 9	ND
Ca_v1.3/SA	−7.01 ± 0.11	0.82 ± 0.2	90 ± 5	−6.01 ± 0.40	−49 ± 0.8	−29 ± 1.5	ND
Ca_v1.3/SA	N = 4 to 5	0.82 ± 0.2	90 ± 5	N = 3–18	N = 12	N = 12	ND

ND, Not determined.
↵^a Data collected using balanced NMDG solutions.