Fetal metformin AUC and AUC ratios in Oct3+/+ and Oct3−/− pregnant mice
Data are presented as mean with 95% confidence intervals in parentheses.
| Oct3+/+ | Oct3−/− | % Change | |
|---|---|---|---|
| AUCfetal, 0–480 min (μg/g*min) | 127 (82.6, 146) | 77.2 (66.9, 87.4)* | 39% |
| AUC0–480 fetal-to-maternal ratio | 0.21 (0.14, 0.25) | 0.15 (0.13, 0.18)* | 29% |
| AUCfetal, 0-∞ (μg/g*min) | 181 (136, 204) | 95.7 (86.2, 104)* | 47% |
| AUC0-∞ fetal-to-maternal ratio | 0.27 (0.20, 0.32) | 0.17 (0.15, 0.20)* | 44% |
↵* Significantly different from Oct3+/+ (P < 0.05).