TABLE 2

EC50, Hill coefficient, and maximal responses of DAVA and GABA produced by mutant Hco-UNC-49BC receptors H142C and C224A

CompoundH142CC224A
EC50 ± S.E. (µM)
(Hill Coefficient ± S.E.)% Maximal GABA ± S.E.nEC50 ± S.E. (µM)
(Hill Coefficient ± S.E.)% Maximal GABA ± S.E.n
DAVA1353.2 ± 246.2 (1.15 ± 0.16)86.5 ± 2.8a72464 ± 107.2 (2.18 ± 0.1)21.2 ± 2.75
GABA2.7 ± 0.22 (1.44 ± 0.07)a100732.56 ± 2.29 (1.37 ± 0.11)1007
  • a Values statistically significantly different from C224A (P < 0.001).