Biologic activities of selected compounds predicted by the PASS Online web service for the mechanism of action
| Mechanism of Action | Compound Number | |||||||
|---|---|---|---|---|---|---|---|---|
| Hyp9 | 64402 | 50741 | 51164 | |||||
| Structure identity (%) | 100 | 100 | 91.82 | 91.82 | 90.24 | 90.24 | 88.12 | 88.12 |
| Analog | Hyp9 | Hyp9 | HYP1 | HYP1 | 880395 | 880395 | 871099 | 871099 |
| Activity | Pa | Pi | Pa | Pi | Pa | Pi | Pa | Pi |
| Calcium channel (voltage-sensitive) activator | 0.540 | 0.052 | 0.546 | 0.048 | 0.494 | 0.083 | 0.624 | 0.017 |
| Neuropeptide Y2 antagonist | 0.229 | 0.159 | 0.217 | 0.177 | 0.571 | 0.008 | 0.629 | 0.004 |
| Sigma receptor agonist | 0.157 | 0.146 | 0.198 | 0.135 | 0.288 | 0.082 | 0.484 | 0.028 |
| Calcium channel activator | 0.224 | 0.104 | 0.291 | 0.038 | 0.338 | 0.026 | 0.368 | 0.018 |
| Acetylcholine neuromuscular blocking agent | — | — | 0.599 | 0.023 | 0.484 | 0.084 | 0.481 | 0.087 |
—, no data available.