Potency of Leu8-OT and Pro8-OT at inducing membrane hyperpolarization in mOTR and hOTR CHO cells
| Parameter | Ligand | Rank Order Potency | |
|---|---|---|---|
| Leu8-OT | Pro8-OT | ||
| pM | nM | ||
| mOTR | |||
| EC50 | 11.6 | 1.1 | Leu8-OT > Pro8-OT |
| 95% CI | 3.1–47.3 | 0.2–5.6 | |
| R2 | 0.71 | 0.53 | |
| hOTR | |||
| EC50 | 25.6 | 13.23 | Leu8-OT > Pro8-OT |
| 95% CI | 4.4–150.0 | 2.4–73.6 | |
| R2 | 0.53 | 0.54 | |