TABLE 2
Potency of Leu
8
-OT and Pro
8
-OT at inducing membrane hyperpolarization in mOTR and hOTR CHO cells
Parameter
Ligand
Rank Order Potency
Leu
8
-OT
Pro
8
-OT
pM
nM
mOTR
EC
50
11.6
1.1
Leu
8
-OT > Pro
8
-OT
95% CI
3.1–47.3
0.2–5.6
R
2
0.71
0.53
hOTR
EC
50
25.6
13.23
Leu
8
-OT > Pro
8
-OT
95% CI
4.4–150.0
2.4–73.6
R
2
0.53
0.54