Current density (pA/pF) at mouse α3β4 nAChRs under different chronic (24–30 h) treatments
Cells were studied 52.5–52.75 h after the start of transfection and 26.5–27.0 h after the start of incubation in no drug-containing media or after addition of menthol and/or nicotine (both durations are averages). Mean ± S.E. values are represented in the table.
| Chronic Treatment | Control | (−)-Menthol | Nicotine | Nicotine and (−)-Menthol |
|---|---|---|---|---|
| (−)-Menthol (nM) | 0 | 500 | 0 | 500 |
| Nicotine (µM) | 0 | 0 | 250 | 250 |
| Cell capacitance (pF)a | 24.1 ± 3.0 | 21.9 ± 2.1 | 22.5 ± 1.9 | 22.9 ± 1.9 |
| Current density (pF/pA)a | −129.7 ± 22.9 | −102.7 ± 19.6 | −62.7 ± 10.4 | −71.9 ± 12.3 |
| N | 27 | 28 | 19 | 20 |
↵a P > 0.05 for one-way ANOVA with post-hoc Tukey HSD test.