Differential OATP protein expression in cancer tissues

See the text for references for this table.

ProteinMalignant Tissue Distributiona
OATP1A2Increased expression: breast, pancreas, bone, some lung cancer cell lines
Decreased expression: colon, some lung cell lines
OATP1B1Increased expression: breast, pancreas, prostate, ovary, lung, colon
Decreased expression: liver
OATP1B3Increased expression: colon, pancreas, lung, breast, prostate, ovary, lung, stomach, gallbladder
Decreased expression: liver
OATP2B1Increased expression: lung (conflicting evidence), breast, colon, bone
Decreased expression: none reported
  • a Increased and decreased refer to expression of the transporter in malignant tissue compared with normal tissue of the same type.