The ER retention sites predicted for UGT isoforms
| Isoform | Motif/Predicted Position | Evidence | References |
|---|---|---|---|
| UGT common | DM | Nucleotide sequence | Iyanagi et al., 1986 |
| Fusion protein with CD4/8 | Jackson et al., 1990; | ||
| Fusion protein with ErbB2 | Kinosaki et al., 1993 | ||
| Fusion protein with CD4 | This study | ||
| UGT2B1 | Within 24-493 | Truncated mutant | Meech et al., 1996 |
| UGT1A6 | Within 141-240 | Fusion protein with GFP | Ouzzine et al., 1999 |
| UGT1A(6) | 490-506 (TMD) | Fusion proteins with CD4 | Barré et al., 2005 |
| Deletion mutants | Ouzzine et al., 2006 | ||
| UGT1A(1) | Within 26-434 | Splice variant i2 | Bellemare et al., 2010 Girard et al., 2007 Guillemette et al., 2014 Lévesque et al., 2007 Rouleau et al., 2014 |
| UGT2B7 | Within 24-369 | Splice variant i4 | Ménard et al., 2013 |
| UGT2B7 | Within 24-492 | Truncated mutant | Miyauchi et al., 2015 |
| UGT2B7 | 24-492 (ΔTM) | Serial deletion mutants | This study |
| 24-252 (Δ1) | |||
| 24-133 (Δ5) | |||
| 253-492 (Δ7) | |||
| 471-492 (Δ8-Δ11) | |||
| No obvious retention signal can be specified (Lack of a putative export signal) |
TMD, TM domain.