Cytotoxic effects of DJ95 against parental and drug-selected ABCB1-, ABCC1-, and ABCG2-overexpressing cancer cell lines
The IC50 values represent the mean ± S.D. of three independent experiments performed in triplicate.
—, data not available.
| Treatment | IC50 ± S.D. | ||||
|---|---|---|---|---|---|
| KB-3-1 | KB-C2 (ABCB1) | KB-CV60 (ABCC1) | NCI-H460 | NCI-H460/MX20 (ABCG2) | |
| nM | nM | nM | nM | nM | |
| DJ95 | 23.5 ± 2.2 | 719.5 ± 181.5 | 35.9 ± 4.5 | 673.0 ± 111.7 | 5361.5 ± 645.5 |
| Paclitaxel | 9.2 ± 2.1 | 1918.5 ± 106.3 | 120.0 ± 14.6 | >10,000 | >10,000 |
| Colchicine | 23.9 ± 4.9 | 7445.3 ± 446.3 | 91.7 ± 7.7 | >10,000 | >10,000 |
| Vincristine | 1.3 ± 0.2 | 748.8 ± 99.8 | 218.6 ± 1.9 | >10,000 | >10,000 |
| Mitoxantrone | — | — | — | 118.7 ± 40.2 | 2456.5 ± 420.4 |
| Cisplatin | 2024.5 ± 463.7 | 2871.2 ± 115.3 | 1796.5 ± 198.8 | 2226.6 ± 179.5 | 2870.6 ± 281.7 |