TABLE 2

Cytotoxic effects of DJ95 against parental and gene-transfected ABCB1-, ABCC1-, and ABCG2-overexpressing cell lines

The IC50 values represent the mean ± S.D. of three independent experiments performed in triplicate.

—, data not available.

TreatmentIC50 ± S.D.
HEK293/pcDNA3.1HEK293/ABCB1HEK293/ABCC1HEK293/ABCG2-R482
nMnMnMnM
DJ95330.0 ± 44.1314.7 ± 73.11213.9 ± 241.62869.2 ± 123.3
Paclitaxel34.6 ± 6.33496.0 ± 657.8>10,000>10,000
Colchicine112.1 ± 41.5>10,000>10,000>10,000
Vincristine99.4 ± 23.1>10,000>10,000>10,000
Mitoxantrone108.0 ± 27.51209.7 ± 111.4
Cisplatin2510.1 ± 362.62583.1 ± 474.52584.1 ± 151.82475.3 ± 127.4