Relative efficacy to Imax acetylcholine (S.E.M.)
| Drug | WT | n | TyrA/TyrOMe | n |
|---|---|---|---|---|
| NS6740 | 0.13 ± 0.1 | 15 | ||
| ACh | 1.00 ± 0.039 | 19 | 0.325 ± 0.056 | 16 |
| NS6740 + PNU-120596 | 0.027 ± 0.004 | 19 | 1.9 ± 0.32 | 16 |
| ACh | 1.25 ± 0.10 | 19 | 0.60 ± 0.071 | 16 |
| ACh + PNU-120596 | 1.4 ± 0.18 | 18 | 2.1 ± 0.34 | 16 |
ACh, acetylcholine; NS6740, 1,4-diazabicyclo[3.2.2]nonan-4-yl(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanone; PNU-120596, 1-(5-chloro-2,4-dimethoxy-phenyl)-3-(5-methyl-isoxazol-3-yl)-urea; WT, wild type.