Comparison of efficacies between C2, C4, C5, C9, and C15 conjugates to inhibit BC cell viability and migration
Each value represents the mean ± S.D. of maximum inhibitory effect of each drug conjugate represented as the percentage of vehicle for viability and the percentage of baseline for migration assays.
| Cell Type | C2 | C4 | C5 | C9 | C15 |
|---|---|---|---|---|---|
| MCF-7 | |||||
| Viability | 66 ± 2 abcde | 29 ± 7 abcde | 10 ± 0.3 ab | 65 ± 2 abcde | 86 ± 2.4 acde |
| Migration | 20 ± 11 ab | 10 ± 15 ab | 2 ± 2 a | 19 ± 11 ab | −13 ± 5 d |
| MMC | |||||
| Viability | 79 ± 6 a | 57 ± 22 ab | 65 ± 7 ab | 79 ± 9 a | 97 ± 11 cde |
| Migration | 44 ± 34 abcde | 7 ± 40 a | 1 ± 2.3 a | 39 ± 39 abe | −32 ± 5 |
| MDA-MB-231 | |||||
| Viability | 63 ± 1.4 abd | 98 ± 22 ce | 75 ± 1.7 ad | 68 ± 2 abd | 104 ± 6.7 ce |
| Migration | 33 ± 13 ab | 30 ± 36 ab | 10 ± 7 ab | 35 ± 10 abcde | −43 ± 27 acde |
| BT-549 | |||||
| Viability | 80 ± 16 abce | 66 ± 4 ab | 67 ± 6 ab | 88 ± 27 cde | 93 ± 7 acde |
| Migration | 42 ± 12 abcd | 20 ± 4 a | 0 ± 0 | 56 ± 29 abcde | −61 ± 14 abcde |
Values were derived from three to nine individual curves fit by nonlinear regression analysis. Data were analyzed by one-way ANOVA followed by the Newman–Keuls post hoc t test where significance was defined as P < 0.05. Letters denote significance between groups as follows: a, P < 0.05 vs. vehicle; b, P < 0.05 vs. C2; c, P < 0.05 vs. C4; d, P < 0.05 vs. C5; e, P < 0.05 vs. C9.