TABLE 1

Top 20 significantly up- or downregulated proteins in Mct6−/− and Mct6+/+ mice in kidney

RankProtein AccessionSymbolProtein NameRatio (KO/WT)Padj valuea
Upregulated
 1Q8K358PiguPhosphatidylinositol glycan anchor biosynthesis class U6.300.0073
 2P11835Itgb2Integrin beta-22.480.0299
 3Q64437Adh7Alcohol dehydrogenase class 4 mu/sigma chain2.310.0422
 4F8VQB6Myo10Unconventional myosin-X1.980.0020
 5Q8CG71P3h2Prolyl 3-hydroxylase 21.890.0211
 6Q7TQK1Ints7Integrator complex subunit 71.810.0243
 7P14483H2-Ab1H-2 class II histocompatibility antigen, A beta chain1.710.0368
 8Q9JI99Sgpp1Sphingosine-1-phosphate phosphatase 11.690.0388
 9Q9DC63Fbxo3F-box only protein 31.610.0272
 10Q60680ChukInhibitor of nuclear factor kappa-B kinase subunit alpha1.600.0458
 11Q99JR5Tinagl1Tubulointerstitial nephritis antigen-like1.560.0427
 12Q9JK23Psmg1Proteasome assembly chaperone 11.520.0273
 13Q64345Ifit3Interferon-induced protein with tetratricopeptide repeats 31.500.0225
 14P17183Eno2Gamma-enolase1.490.0187
 15Q9ERV1Mkrn2Probable E3 ubiquitin-protein ligase makorin-21.480.0158
 16O08739Ampd3AMP deaminase 31.460.0153
 17Q7TMV3Fastkd5FAST kinase domain-containing protein 5, mitochondrial1.430.0224
 18Q99K41Emilin1EMILIN-11.420.0373
 19Q6PF93Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 31.410.0131
 20Q6P4S8Ints1Integrator complex subunit 11.410.0242
Downregulated
 1Q9D1C3PyurfProtein preY, mitochondrial0.060.0033
 2Q9D7G0Prps1Ribose-phosphate pyrophosphokinase 10.480.0492
 3Q8R3L5Slco3a1Solute carrier organic anion transporter family member 3A10.540.0051
 4Q810D6Grwd1Glutamate-rich WD repeat-containing protein 10.550.0475
 5Q8C0L6PaoxPeroxisomal N(1)-acetyl-spermine/spermidine oxidase0.600.0219
 6P60904Dnajc5DnaJ homolog subfamily C member 50.610.0082
 7Q922P9Glyr1Putative oxidoreductase0.630.0224
 8P62482Kcnab2Voltage-gated potassium channel subunit beta-20.630.0163
 9Q99P87RetnResistin0.630.0011
 10Q80UP3DgkzDiacylglycerol kinase zeta0.630.0415
 11Q9CQE7Ergic3Endoplasmic reticulum-Golgi intermediate compartment protein 30.640.0367
 12Q7TT37IkbkapElongator complex protein 10.670.0326
 13Q9Z120Mettl1tRNA (guanine-N(7)-)-methyltransferase0.680.0404
 14Q8R429Atp2a1Sarcoplasmic/endoplasmic reticulum calcium ATPase 10.690.0253
 15Q5SF07Igf2bp2Insulin-like growth factor 2 mRNA-binding protein 20.700.0236
 16O35226Psmd426S proteasome non-ATPase regulatory subunit 40.710.0023
 17Q9Z2C5Mtm1Myotubularin0.740.0291
 18Q6NZB0Dnajc8DnaJ homolog subfamily C member 80.750.0234
 19O70496Clcn7H(+)/Cl(−) exchange transporter 70.760.0258
 20O35609Scamp3Secretory carrier-associated membrane protein 30.770.0248
  • tRNA, transfer RNA.

  • a P values were calculated using a Student’s t test adjusted using the Benjamini-Hochberg false discovery rate method.