TABLE 2

Top 20 significantly up- or downregulated proteins in Mct6−/− and Mct6+/+ mice in liver

RankProtein AccessionSymbolProtein NameRatio (KO/WT)Padj valuea
Upregulated
 1Q9D4H1Exoc2Exocyst complex component 23.660.0095
 2Q8K2L8Trappc12Trafficking protein particle complex subunit 122.620.0030
 3P97426Ear1Eosinophil cationic protein 12.110.0420
 4Q91ZP3Lpin1Phosphatidate phosphatase1.900.0104
 5A2AQ25SktSickle tail protein1.890.0060
 6Q4VA53Pds5bSister chromatid cohesion protein PDS5 homolog B1.750.0420
 7Q4U2R1Herc2E3 ubiquitin-protein ligase1.670.0247
 8Q9D0K1Pex13Peroxisomal membrane protein1.670.0041
 9Q69Z37Samd9lSterile alpha motif domain-containing protein 9-like1.620.0152
 10O35943FxnFrataxin, mitochondrial1.400.0043
 11P16045Lgals1Galectin-11.390.0369
 12P68373Tuba1cTubulin alpha-1C chain1.350.0066
 13Q9D7X8GgctGamma-glutamylcyclotransferase1.340.0165
 14Q9R062Gyg1Glycogenin-11.320.0336
 15Q80XI3Eif4g3Eukaryotic translation initiation factor 4 gamma 31.310.0464
 16Q3URF8Kctd21BTB/POZ domain-containing protein KCTD211.300.0459
Downregulated
 1Q5SX79Shroom1Protein Shroom10.500.0141
 2Q9QUM0Itga2bIntegrin alpha-Iib0.580.0146
 3Q9Z0H1Wdr46WD repeat-containing protein 460.620.0270
 4Q8BXB6Slco2b1Solute carrier organic anion transporter family member 2B10.620.0005
 5Q9DBA9Gtf2h1General transcription factor IIH subunit 10.630.0340
 6Q61136Prpf4bSerine/threonine-protein kinase PRP4 homolog0.650.0342
 7A2CG49KalrnKalirin0.650.0212
 8Q9CWN7Cnot11CCR4-NOT transcription complex subunit 110.650.0169
 9Q8K558Treml1Trem-like transcript 1 protein0.670.0400
 10O88833Cyp4a10Cytochrome P450 4A100.680.0021
 11P62254Ube2g1Ubiquitin-conjugating enzyme E2 G10.680.0064
 12Q6XVG2Cyp2c54Cytochrome P450 2C540.690.0296
 13Q99JF5MvdDiphosphomevalonate decarboxylase0.690.0216
 14Q3UHJ0Aak1AP2-associated protein kinase 10.710.0475
 15Q8K124Plekho2Pleckstrin homology domain-containing family O member 20.720.0293
 16Q3UUQ7Pgap1GPI inositol-deacylase0.730.0017
 17Q920I9Wdr7WD repeat-containing protein 70.740.0179
 18P58735Slc26a1Sulfate anion transporter 10.740.0460
 19Q91V08Clec2dC-type lectin domain family 2 member D0.740.0282
 20Q9CQT9Uncharacterized protein C20orf24 homolog0.740.0143
  • a P values were calculated using a Student’s t test adjusted using the Benjamini-Hochberg false discovery rate method.