TABLE 4

Top five canonical pathways significantly enriched with the differential protein expression data between the Mct6−/− and Mct6+/+ mice

NameP valuea
Kidney
 NF-B activation by viruses7.76 × 10−3
 Lymphotoxin receptor signaling8.13 × 10−3
 Angiopoietin signaling1.02 × 10−2
 CD40 signaling2.42 × 10−2
 Role of NFAT in regulation of the immune response2.42 × 10−2
Liver
 Remodeling of epithelial adherens junctions7.76 × 10−3
 α-tocopherol degradation8.13 × 10−3
 Glycogen biosynthesis II (from UDP-D-glucose)1.02 × 10−2
 Mevalonate pathway I2.42 × 10−2
 Pregnenolone biosynthesis2.42 × 10−2
Colon
 Clathrin-mediated endocytosis signaling7.49 × 10−4
 Glioma invasiveness signaling1.06 × 10−2
 EIF2 signaling1.49 × 10−2
 Triacylglycerol biosynthesis1.61 × 10−2
 Regulation of actin-based motility by rho1.97 × 10−2
  • a P values were calculated using a Fisher’s exact test.