TABLE 5

Top five canonical pathways significantly enhanced, based on the differential transcriptomic data between the Mct6−/− and Mct6+/+ mice

NameP ValueaZ ScoreMolecule
Superpathway of cholesterol biosynthesisb3.72 × 10−82.65Pmvk, Sqle, Idi1, Fdps, Hmgcr, Cyp51a1, Mvd
Superpathway of geranylgeranyldiphosphateb1.22 × 10−62.24Pmvk, Idi1, Fdps, Hmgcr, Mvd
Biosynthesis I (via mevalonate) mevalonate pathway Ib9.55 × 10−62Pmvk, Idi1, Hmgcr, Mvd
Trans, trans-farnesyl diphosphate biosynthesis5.37 × 10−4NaNcIdi1, Fdps
LPS/IL-1 mediated inhibition of RXR functionb8.91 × 10−42Aldh3a2, Il1b, Cyp4a11, Cyp3a5, Pppara, Gstp1, Fabp2, Sult1c2

  • ↵a P values were calculated using a Fisher’s exact test.

  • ↵b Pathway is predicted to be statistically significantly increased (Z ≥ 2).

  • ↵c NaN, not a number.