TABLE 3

Top 20 significantly up- or downregulated proteins in Mct6−/− and Mct6+/+ mice in colon

RankProtein AccessionSymbolProtein NameRatio (KO/WT)Padj valuea
Upregulated
 1P27005S100a8Protein S100-A83.220.0252
 2Q9D1H8Mrpl5339S ribosomal protein L53, mitochondrial2.660.0162
 3Q80X41Vrk1Serine/threonine-protein kinase VRK12.430.0086
 4Q80WC3Tnrc18Trinucleotide repeat-containing gene 18 protein2.250.0002
 5Q9JHZ2AnkhProgressive ankylosis protein2.170.0179
 6Q7TQ62PodnPodocan1.910.0426
 7E9PZQ0Ryr1Ryanodine receptor 11.910.0012
 8Q9QXE7Tbl1xF-box-like/WD repeat-containing protein1.840.0330
 9Q8BN21Vrk2Serine/threonine-protein kinase1.830.0314
 10Q61247Serpinf2Alpha-2-antiplasmin1.830.0129
 11Q62432Smad2Mothers against decapentaplegic homolog 21.790.0408
 12Q3V384Afg1lAFG1-like ATPase1.790.0041
 13Q9DCZ1GmprGMP reductase 11.790.0016
 14Q9CZV8Fbxl20F-box/LRR-repeat protein 201.740.0009
 15Q8BFQ8Gatd1Glutamine amidotransferase-like class 1 domain-containing protein 11.710.0067
 16Q8BFR4GnsN-acetylglucosamine-6-sulfatase1.680.0100
 17Q3TFD2Lpcat1Lysophosphatidylcholine acyltransferase 11.670.0291
 18Q61555Fbn2Fibrillin-21.640.0384
 19Q6P5C5Smug1Single-strand selective monofunctional uracil DNA glycosylase1.600.0028
 20P06684C5Complement C51.580.0221
Downregulated
 1P02802Mt1Metallothionein-10.150.0096
 2P28667Marcksl1MARCKS-related protein0.150.0022
 3Q9CQG0Tmed6Transmembrane emp24 domain-containing protein 60.210.0411
 4Q3TBD2Arhgap45Rho GTPase-activating protein 450.240.0441
 5P02798Mt2Metallothionein-20.330.0144
 6Q8VE97Srsf4Serine/arginine-rich splicing factor 40.390.0078
 7Q9WV02RbmxRNA-binding motif protein, X chromosome0.400.0140
 8Q5DTM8Rnf20E3 ubiquitin-protein ligase BRE1A0.400.0025
 9P52927Hmga2High mobility group protein HMGI-C0.410.0338
 10Q80XU3Nucks1Nuclear ubiquitous casein and cyclin-dependent kinase substrate 10.410.0036
 11P40240Cd9CD9 antigen0.430.0183
 12Q71RI9Kyat3Kynurenine-oxoglutarate transaminase 30.470.0003
 13Q61189Clns1aMethylosome subunit pICln0.470.0002
 14Q69Z69Esco1N-acetyltransferase0.480.0037
 15Q8CH36Slc36a4Proton-coupled amino acid transporter0.480.0029
 16Q7TT18Atf7ipActivating transcription factor 7-interacting protein 10.510.0235
 17P98078Dab2Disabled homolog 20.510.0013
 18Q11127Fut4Alpha-(1,3)-fucosyltransferase 40.520.0018
 19Q9CQ49Ncbp2Nuclear cap-binding protein subunit 20.520.0015
 20Q80YS6Afap1Actin filament-associated protein 10.530.0209
  • a P values were calculated using a Student’s t test adjusted using the Benjamini-Hochberg false discovery rate method.