TABLE 2

P-gp substrates tested in combination with elacridar and tariquidar

CompoundMechanism of Action
Mithramycin AAlcohol dehydrogenase inhibitor
DanusertibAurora-A/B/C kinase inhibitor
TozasertibAurora-A/B/C kinase inhibitor
PHA-793887CDK1,2,3,4,5 inhibitor
RomidepsinHistone deacetylase (HDAC) inhibitor
JNK-IN-7JNK inhibitor
PKI-587mTOR inhibitor
CB 300919NAMPT inhibitor
AST-487RET kinase inhibitor
Sepantronium bromideSurvivin inhibitor
DocetaxelTubulin polymerization promoter
PaclitaxelTubulin polymerization promoter
VinorelbineTubulin polymerization inhibitor
RO495Tyk 2 inhibitor
RA-XIIN/A (Natural product)

  • CDK, cyclin-dependent kinase.