Construct | PMP | CP | GYKI | |||
[Ca2+]i | TEVC | [Ca2+]i | TEVC | [Ca2+]i | TEVC | |
GluA2 | 29 [28–29]*** | 4.3 [4.2–4.4]*** | 2.5 [2.5–2.6]** | 2.5 [2.4–2.6] | 230 [230–230]*** | 20 [19–21] |
blac-GluA2 | 16 [15–18] | 2.4 [2.3–2.5] | 1.1 [1.0–1.2] | 2.4 [2.3–2.6] | 120 [110–120] | 25 [25–26] |
K511G | >100*** | 9.6 [9.3–9.9]*** | 9.3 [7.0–12]*** | 3.3 [3.1–3.4] | >2000*** | 62 [49–78]*** |
P512G | 9.8 [8.4–11]* | 4.4 [4.3–4.5]*** | 5.5 [5.0–6.0]*** | 7.5 [7.2–7.8]*** | 140 [100–180] | 79 [75–84]*** |
V514G | >100*** | 29 [26–31]*** | >100*** | 10 [9.6–10]*** | >2000*** | 620 [450–850]*** |
V514A | >100*** | 4.7 [4.4–4.9]*** | 27 [23–31]*** | 3.3 [3.1–3.6] | >2000*** | 11 [10–12]*** |
V514D | 19 [14–26] | 11 [11–11]*** | 6.0 [5.8–6.3]*** | 4.0 [3.8–4.3] | >2000*** | 69 [66–73]*** |
V514W | 87 [71–110]*** | 2.3 [2.3–2.4] | 4.2 [3.7–4.7]*** | 0.9 [0.9–1.0]*** | >2000*** | 18 [18–19] |
F515G | 4.1 [3.7–4.5]*** | 1.6 [1.6–1.6]*** | 0.7 [0.7–0.8] | 1.6 [1.6–1.7] | 20 [19–21]*** | 7.9 [7.7–8.1]*** |
F515A | 4.5 [3.7–5.6]*** | N.D. | 0.4 [0.4–0.4]** | N.D. | 49 [42–57]*** | N.D. |
S516G | 23 [19–27] | N.D. | 3.5 [3.3–3.8]*** | N.D. | 670 [520–860]*** | N.D. |
F517G | 1.0 [1.0–1.1]*** | N.D. | 0.3 [0.3–0.3]*** | N.D. | 13 [12 to 13]*** | N.D. |
F517A | 4.9 [4.6–5.2]*** | N.D. | 2.4 [2.1–2.6] | N.D. | 53 [47–58]*** | N.D. |
L518A | 2.9 [2.5–3.2]*** | 3.8 [3.7–3.9]*** | 0.8 [0.8–0.8] | 1.9 [1.8–1.9] | 28 [27–30]*** | 28 [27–29] |
D519G | 10 [9.2–11]** | N.D. | 3.7 [3.4–4.0]*** | N.D. | 19 [17–20]*** | N.D. |
D519N | 24 [17–34] | 3.3 [3.2–3.5]*** | 61 [18–210]*** | 7.4 [7.0–7.8]*** | 55 [47–63]*** | 8.1 [7.7–8.5]*** |
A522G | 17 [14–20] | N.D. | 1.7 [1.6–1.8] | N.D. | 310 [280–350]*** | N.D. |
A522S | 16 [14–18] | N.D. | 2.4 [2.2–2.7] | N.D. | 510 [400–650]*** | N.D. |
Y523G | 12 [10–14] | N.D. | 1.2 [1.2–1.3] | N.D. | 91 [77–1107] | N.D. |
Y523P | 18 [12–27] | N.D. | 3.1 [2.8–3.4]** | N.D. | 370 [320–430]*** | N.D. |
Y523R | 15 [13–17] | N.D. | 1.8 [1.6–1.9] | N.D. | 84 [76–93]* | N.D. |
E524G | 9.5 [8.7–10]*** | N.D. | 0.5 [0.5–0.5]* | N.D. | 48 [43–52]*** | N.D. |
E524D | 23 [19–27] | 2.0 [1.9–2.1]*** | 5.0 [3.9–6.4]*** | 1.6 [1.5–1.6] | 140 [110–180] | 14 [14–15]** |
M527G | 8.9 [7.9–10]** | N.D. | 0.5 [0.4–0.6] | N.D. | 120 [100–140] | |
S615A | >100*** | 2.2 [2.1–2.3] | 3.5 [3.3–3.7]* | 0.2 [0.2–0.2]*** | >2000*** | 31 [14–66] |
Y616F | N.D. | 0.9 [0.5–1.7]*** | N.D. | 1.8 [1.6–1.9] | N.D. | 26 [15–46] |
F623A | >100*** | >100*** | 12 [7.2–21]*** | 51 [4.4–590]*** | 100 [88–120] | 87 [35–210]*** |
E782G | 12 [11–13] | N.D. | 1.1 [1.1–1.2] | N.D. | 100 [97–110] | N.D. |
K783G | 27 [19–39]** | N.D. | 2.7 [2.6–2.8]* | N.D. | 170 [160–180]** | N.D. |
T784G | 8.5 [7.3–9.8]*** | 7.9 [7.6–8.2]*** | 1.1 [1.0–1.2] | 2.5 [2.5–2.5] | 23 [21–25]*** | 22 [22–23] |
S785G | 10 [9.0–11]** | 3.5 [3.4–3.7]*** | 1.1 [1.0–1.2] | 1.7 [1.6–1.7] | 39 [36–42]*** | 12 [12–12]*** |
A786G | 1.4 [1.3–1.6]*** | 2.7 [2.6–2.7]** | 0.6 [0.5–0.6] | 3.1 [3.0–3.2] | 18 [17–19]*** | 11 [11–12]*** |
L787A | 37 [18–74]*** | N.D. | 7.1 [6.6–7.6]*** | N.D. | 630 [500–780]*** | N.D. |
S788G | 16 [14–18] | N.D. | 0.6 [0.6–0.6] | N.D. | 92 [77–110] | N.D. |
L789G | 4.8 [4.3–5.4]*** | N.D. | 0.4 [0.3–0.4]*** | N.D. | 61 [51–73]*** | N.D. |
S790G | 9.9 [5.4–18]* | N.D. | 1.5 [1.4–1.7] | N.D. | 140 [100–180] | N.D. |
N791G | 8.7 [6.4–12]*** | N.D. | 15 [9.2–24]*** | N.D. | 350 [300–420]*** | N.D. |
N791A | >100*** | 1.5 [1.5–1.6]*** | >100*** | 11 [10–13]*** | >2000*** | 21 [21–22] |
N791F | 3.7 [3.5–3.8]*** | N.D. | 1.9 [1.9–2.0] | N.D. | 22 [20–23]*** | N.D. |
N791L | 14 [13–15] | N.D. | 25 [19–33]*** | N.D. | 66 [62–69]*** | N.D. |
V792I | 14 [12–16] | 1.2 [1.2–1.3]*** | 13 [9.2–17]*** | 2.1 [2.0–2.2] | 170 [140–200]* | 11 [10–11]*** |
A793G | 12 [8.9–17] | N.D. | 1.1 [1.0–1.2] | N.D. | 180 [150–220]*** | N.D. |
A793D | 27 [18–41]** | N.D. | 170 [8.6–3500]*** | N.D. | 190 [170–200]*** | N.D. |
A793H | 15 [12–18] | N.D. | 3.7 [3.0–4.5]*** | N.D. | 110 [110–120] | N.D. |
G794D | 37 [30–46]*** | 5.5 [5.4–5.7]*** | 11 [8.4–14]*** | 2.8 [2.7–2.9] | 280 [250–310]*** | 40 [39–41]* |
V795G | 15 [10–21] | N.D. | 1.1 [0.9–1.2] | N.D. | 87 [74–100] | N.D. |