TABLE 2

Simulation of agonist concentration-response relationships upon changes in binding or transducer slopes and τA

Data were simulated using the Black-Leff model (eq. 1) or the cooperative agonist operational model (eq. 2) and a Hill equation (eq. 9) was fitted to simulated data to determine agonist potency, maximum effect, and Hill slope.

τAeq. 1; nT 1eq. 1; nT 3eq. 2; nT 1, nB 1eq. 2; nT 1, nB 3eq. 2; nT 3, nB 3
pEC50EmaxnHpEC50EmaxnHpEC50EmaxnHpEC50EmaxnHpEC50EmaxnH
1004.9991.04.91003.04.9991.03.6993.03.61008.9
104.0911.03.91002.74.0911.03.3913.03.21007.6
13.2511.02.6501.53.2511.03.0513.02.8514.5
0.33.0241.02.43.01.43.0241.03.0243.02.73.03.9
0.13.09.01.02.30.11.43.09.01.03.09.03.02.70.13.8
  • pEC50, agonist potency.