TABLE 1

Hill equation parameters for drug dose responses

Parameters derived from least-squares fits of the Hill equation to the dose responses of Po in Fig 1. Values are mean ± S.E.; n = number of samples for each concentration: Embedded Image.

DrugCaM nMVoltage mVIC50 µMHPmax%n
Phenytoin1004016 ± 41.1 ± 0.445 ± 514–19
Phenytoin04015 ± 31.8 ± 0.646 ± 313–18
Phenytoin100−4019 ± 61.0 ± 0.339 ± 613–17
Phenytoin0−4013 ± 31.0 ± 0.740 ± 614–27
Dantrolene100400.13 ± 0.070.6 ± 0.351 ± 513–15
Dantrolene100−400.14 ± 0.031.5 ± 0.553 ± 314–18