TABLE 1

Log D of diclofenac at 37°C as a function of medium pH determined by UV-Vis derivative spectrophotometry

Log D values are presented as means ± S.D. of at least three independent assays. Log Do/w values from MarvinSketch calculator (ChemAxon) are also presented.

pHLog DLog Do/w
3.04.13 ± 0.074.22
5.03.74 ± 0.073.21
7.43.49 ± 0.031.10
  • Log Do/w, octanol:water log D prediction.