TABLE 4

Long-range distances (d) and correlation lengths (ξ) calculated from the first-order peak(s) of the SAXS patterns of DMPC bilayers as a function of temperature, pH, and drug:lipid molar ratio (x)

The displayed values are the means ± S.D. of at least three recorded frames. The calculated membrane concentration of diclofenac ([Drug]m) is also presented. —, no defined Bragg peaks were observed,

T/°CpHx[Drug]m/Md1ξ1d2ξ2
103.00.000.0065.5 ± 0.28208 ± 29961.3 ± 0.17796 ± 77
0.080.1272.6 ± 0.27916 ± 22269.6 ± 0.25828 ± 176
0.160.2472.9 ± 0.46902 ± 99768.7 ± 0.6558 ± 113
5.00.000.0066.8 ± 0.17035 ± 3057.0 ± 0.13111 ± 135
0.080.1284.1 ± 0.25646 ± 30776.4 ± 0.13250 ± 118
0.160.24
7.40.000.0066.1 ± 0.19914 ± 3157.4 ± 0.14557 ± 45
0.080.1292 ± 71588 ± 31079 ± 32120 ± 303
0.160.24
373.00.000.0065.5 ± 0.36503 ± 32859.0 ± 0.61596 ± 194
0.080.1264.9 ± 0.111,359 ± 173463.4 ± 0.19804 ± 428
0.160.2486 ± 22960 ± 26368 ± 1168 ± 51
5.00.000.0061.6 ± 0.110,814 ± 29957.7 ± 0.16909 ± 159
0.080.1278 ± 11321 ± 28169.7 ± 0.72811 ± 25
0.160.24
7.40.000.0060.8 ± 0.16957 ± 20757.0 ± 0.111,026 ± 1004
0.080.1276 ± 22766 ± 4369 ± 12423 ± 465
0.160.24